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Search Results for " notch inhibitor 1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T16341 Notch inhibitor 1 Others
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.
T6861 IMR-1 Gamma-secretase
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid Compound W Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T6474 Divalproex Sodium Valproate semisodium,Epival HDAC
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...
TP1540 Jagged-1188-204) Jagged-1 188-204 Gamma-secretase
Jagged-1188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay...
T35566 RBPJ Inhibitor-1 RIN1 Gamma-secretase
RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1].
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T3521 γ-Secretase-IN-1 Compound E Beta Amyloid , Gamma-secretase
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
T2842 Tangeretin NSC53909,Tangeritin,NSC618905 Apoptosis , Gamma-secretase
Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc...
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